Young patients, especially females, Aboriginals, and recipients of social assistance, are at highest risk.Īcetaminophen is the most commonly implicated drug in cases of acute liver failure (ALF) predominantly due to its widespread availability. Hospitalization rates for AO, particularly intentional ingestions, have fallen in our Canadian health region between 19. Risk factors for AO included female sex (RR 2.19 P < 0.0005), Aboriginal status (RR 4.04 P < 0.0005), and receipt of social assistance (RR 5.15 P < 0.0005). Accidental overdoses decreased between 19, but increased to above baseline levels by 2004 (2004 vs.
Hospitalization rates for intentional overdoses fell from 16.6 per 100,000 in 1995 to 8.6 per 100,000 in 2004 (2004 vs. Whereas rates fell 46% in individuals under 50 years, a 50% increase was seen in those ≥ 50 years. This decline was greater in females than males (46% vs. Methodsġ,543 patients hospitalized for AO in the Calgary Health Region (population ~1.1 million) between 19 were identified using administrative data. We examined temporal trends and sociodemographic risk factors for AO in a large Canadian health region. Acetaminophen overdose (AO) is the most common cause of acute liver failure.
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